Liu P, Ashe KH. (2021) The molecular implications of a caspase-2-mediated site-specific tau cleavage in tauopathies. Neural Regen Res. 6(9):1774-1775.
Teravskis PJ, Oxnard BR, Miller EC, Kemper L, Ashe KH, Liao D. (2021) Phosphorylation in two discrete tau domains regulates a stepwise process leading to postsynaptic dysfunction. J. Physiol. 599(9):2483-2498.
Gamache JE, Kemper L, Steuer EL, Leinonen-Wright K, Choquette JM, Hlynialuk C, Benzow K, Vossel KA, Xia W, Koob MD, Ashe KH. (2020) Developmental pathogenicity of 4-repeat human tau is lost with the P301L mutation in genetically matched tau-transgenic mice. J Neurosci. 40(1):220-236.
Ashe KH. (2020) The biogenesis and biology of amyloid β oligomers in the brain. Alzheimers Dement. 16(11):1561-1567.
Teravskis PJ, Ashe KH, Liao D. (2020) The Accumulation of Tau in Postsynaptic Structures: A Common Feature in Multiple Neurodegenerative Diseases? Neuroscientist. 26(5-6):503-520.
(2020) A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals. Sci Rep. 10(1):3869.
. (2019) A Soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease. Acta Neuropathol Commun. 7(1):124.
Gamache J, Benzow K, Forster C, Kemper L, Hlynialuk C, Furrow E, Ashe KH, Koob MD. (2019) Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice. Nat Commun. 10(1):2479.
Grant MKO, Shapiro SL, Ashe KH, Liu P, Zahs KR. (2019) A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins. Biol Proced Online. 21:6.
Grant MKO, Handoko M, Rozga M, Brinkmalm G, Portelius E, Blennow K, Ashe KH, Zahs KR, Liu P. (2019) Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments. PLoS One. 14(2):e0212815.
Liu P, Reichl JH, Rao ER, McNellis BM, Huang ES, Hemmy LS, Forster CL, Kuskowski MA, Borchelt DR, Vassar R, Ashe KH, Zahs KR. (2019) Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice. J Alzheimers Dis. 56(2):743-761.
Liu P, Smith BR, Huang ES, Mahesh A, Vonsattel JPG, Petersen AJ, Gomez-Pastor R, Ashe KH. (2019) A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients. Acta Neuropathol Commun. 7(1):111.
Smith BR, Nelson KM, Kemper LJ, Leinonen-Wright K, Petersen A, Keene CD, Ashe KH. (2019) A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease. Acta Neuropathol Commun. 7(1):124.
Liu P, Reichl JH, Rao ER, McNellis BM, Huang ES, Hemmy LS, Forster CL, Kuskowski MA, Borchelt DR, Vassar R, Ashe KH, Zahs KR. (2017) Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice. Journal of Alzheimer’s Disease. 56(2):743-761.
Zhao X, Kotilinek LA, Smith B, Hlynialuk C, Zahs K, Ramsden M, Cleary J, Ashe KH. (2016) Caspase-2 cleavage of tau reversibly impairs memory. Nature Medicine. 22(11):1268-1276.
Liu P, Reed MN, Kotilinek LA, Grant MKO, Forster CL, Qiang W, Shapiro SL, Reichl JH, Chiang ACA, Jankowsky JL, Wilmot CM, Cleary JP, Zahs KR, Ashe KH. (2015) Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration. Cell Reports. 11(11):1760-1771.
Liu P, Paulson JB, Forster CL, Shapiro SL, Ashe KH, Zahs KR. (2015) Characterization of a Novel Mouse Model of Alzheimer’s Disease–Amyloid Pathology and Unique β-Amyloid Oligomer Profile. PLoS One. 10(5).
Weitzner DS, Engler-Chiurazzi EB, Kotilinek LA, Ashe KH, Reed MN. (2015) Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment. JoVE. 100: 52706.
Zahs KR, Ashe KH. More than a FAD: the in vivo effects of disease-linked presenilin-1 mutations. (2015) Neuron. 85(5):893-5.
Qi Y, Klyubin I, Harney SC, Hu N, Cullen WK, Grant MK, Steffen J, Wilson EN, Do Carmo S, Remy S, Fuhrmann M, Ashe KH, Cuello AC, Rowan MJ. (2014) Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents. Acta Neuropathol Commun. 2:175.
Ashe KH, Aguzzi A. (2013) Prions, prionoids and pathogenic proteins in Alzheimer disease. Prion. 7(1):55-9.
Handoko M, Grant M, Kuskowski M, Zahs KR, Wallin A, Blennow K, Ashe KH. (2013) Correlation of specific amyloid-β oligomers with tau in cerebrospinal fluid from cognitively normal older adults. JAMA Neurol. 70(5):594-9.
SE, Sherman MA, Grant M, Kuskowski M, Schneider JA, Bennett DA, Ashe KH. (2013) Brain amyloid-β oligomers in ageing and Alzheimer’s disease. Brain. 136(5):1383-98.
Zahs KR, Ashe KH. (2013) β-Amyloid oligomers in aging and Alzheimer’s disease. Front Aging Neurosci. 4;5:28.
De Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. (2012) Propagation of tau pathology in a model of early Alzheimer’s disease. Neuron. 73(4):685-97.
Orr ME, Pitstick R, Canine B, Ashe KH, Carlson GA. (2012) Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau. PLoS One. 7(6):e39328.
Liu P, Kemper LJ, Wang J, Zahs KR, Ashe KH, Pasinetti GM. (2011) Grape seed polyphenolic extract specifically decreases aβ*56 in the brains of Tg2576 mice. J Alzheimers Dis. 26(4):657-66.
McCarten JR, Anderson P, Kuskowski MA, McPherson SE, Borson S. (2011) Screening for cognitive impairment in an elderly veteran population: acceptability and results using different versions of the Mini-Cog. J Am Geriatr Soc. 59(2):309-13.
Reed MN, Hofmeister JJ, Jungbauer L, Welzel AT, Yu C, Sherman MA, Lesné S, LaDu MJ, Walsh DM, Ashe KH, Cleary JP. (2011) Cognitive effects of cell-derived and synthetically derived Aβ oligomers. Neurobiol Aging. 32(10):1784-94.
Ashe KH, Zahs KR. (2010) Probing the biology of Alzheimer’s disease in mice. Neuron. 66(5): 631-45.
Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK, Pitstick R, Carlson GA, Lanier LM, Yuan LL, Ashe KH, Liao D. (2010) Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron. 68:1067-1081.
Reed MN, Liu P, Kotilinek LA, Ashe KH. (2010) Effect size of reference memory deficits in the Morris water maze in Tg2576 mice. Behav Brain Res. 212(1):115-20.
Zahs KR, Ashe KH. (2010) ‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer’s disease? Trends Neurosci. 33:381-389.
Kotilinek LA, Westerman MA, Wang Q, Panizzon K, Lim GP, Simonyi A, Lesné S, Falinska A, Younkin LH, Younkin SG, Rowan M, Cleary J, Wallis RA, Sun GY, Cole G, Frautschy S, Anwyl R, Ashe KH. (2008) Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain, 131(Pt3):651-64.
Lesné S, Kotilinek L, Ashe KH. (2008) Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function. Neuroscience, 151:745-749.
Paulson JB, Ramsden M, Forster C, Sherman MA, McGowan E, Ashe KH. (2008) Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer’s disease. Am J Pathol. 173(3):762-72.
Poling A, Morgan-Paisley K, Panos JJ, Kim EM, O’Hare E, Cleary JP, Lesné S, Ashe KH, Porritt M, Baker LE. (2008) Oligomers of the amyloid-beta protein disrupt working memory: confirmation with two behavioral procedures. Behav Brain Res. 193(2):230-4.
Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT. (2008) In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci. 28(4):862-7.
Ashe KH. (2007) A tale about tau. N Engl J Med. 357(9):933-5.
Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puolivali J, Lesné S, Ashe KH, Muchowski PJ, Mucke L. (2007) Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J Biol Chem. 282:23818-23828.
Ma H, Lesné S, Kotilinek L, Steidl-Nichols JV, Sherman M, Younkin L, Younkin S, Forster C, Sergeant N, Delacourte A, Vassar R, Citron M, Kofuji P, Boland LM, Ashe KH. (2007) Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. Proc Natl Acad Sci U.S.A. 104(19):8167-72.
Ashe KH. (2006) Molecular basis of memory loss in the Tg2576 mouse model of Alzheimer’s disease. J Alzheimers Dis. 9(3 Suppl):123-6.
Ashe KH. (2006) In search of the molecular basis of memory loss in Alzheimer disease. Alzheimer Dis Assoc Disord. 20(4):200-1.
Spires TL, Orne JD, SantaCruz K, Pitstick R, Carlson GA, Ashe KH, Hyman BT. (2006) Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. Am J Pathol. 168:1598-1607.
Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH. (2006) A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 440:352-357.
Ashe KH. (2005) Mechanisms of memory loss in Abeta and tau mouse models. Biochem Soc Trans. 33(Pt 4):591-4.
Lesné S, Kotilinek L. (2005) Amyloid plaques and amyloid-beta oligomers: an ongoing debate. J Neurosci. 25(41):9319-20.
Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, SantaCruz K, Guimaraes A, Yue M, Lewis J, Carlson G, Hutton M, Ashe KH. (2005) Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci. 25:10637-10647.
SantaCruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, Kuskowski M, Hyman B, Hutton M, Ashe KH. (2005) Tau suppression in a neurodegenerative mouse model improves memory function. Science. 309:476-481.
Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, Hyman BT, Younkin S, Ashe KH. (2002) Reversible memory loss in a mouse transgenic model of Alzheimer’s disease. J Neurosci. 22(15):6331-5.
Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, Carlson GA, Younkin SG, Ashe KH. (2002) The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer’s disease. J Neurosci. 22(5):1858-67.
Ashe KH. (2001) Learning and memory in transgenic mice modeling Alzheimer’s disease. Learn Mem. 8(6):301-8.
Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG. (2001) Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer’s disease. J Neurosci. 21(2):372-81.
Ashe KH. (2000) Synaptic structure and function in transgenic APP mice. Ann N Y Acad Sci. 924:39-41.
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G. (1996) Correlative memory deficits, Aβ* elevation, and amyloid plaques in transgenic mice. Science. 274:99-102.
Gamache JE, Kemper L, Steuer EL, Leinonen-Wright K, Choquette JM, Hlynialuk C, Benzow K, Vossel KA, Xia W, Koob MD, Ashe KH. (2020) Developmental pathogenicity of 4-repeat human tau is lost with the P301L mutation in genetically matched tau-transgenic mice. J Neurosci. 40(1):220-236.
. (2019) A Soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease. Acta Neuropathol Commun. 7(1):124.
Teravskis PJ, Oxnard BR, Miller EC, Kemper L, Ashe KH, Liao D. (2019) Phosphorylation in two discrete tau domains regulates a stepwise process leading to postsynaptic dysfunction. J. Physiol. [Epub ahead of print]
Gamache J, Benzow K, Forster C, Kemper L, Hlynialuk C, Furrow E, Ashe KH, Koob MD. (2019) Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice. Nat Commun. 10(1):2479.
Grant MKO, Shapiro SL, Ashe KH, Liu P, Zahs KR. (2019) A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins. Biol Proced Online. 21:6.
Grant MKO, Handoko M, Rozga M, Brinkmalm G, Portelius E, Blennow K, Ashe KH, Zahs KR, Liu P. (2019) Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments. PLoS One. 14(2):e0212815.
Liu P, Reichl JH, Rao ER, McNellis BM, Huang ES, Hemmy LS, Forster CL, Kuskowski MA, Borchelt DR, Vassar R, Ashe KH, Zahs KR. (2019) Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice. J Alzheimers Dis. 56(2):743-761.
Liu P, Smith BR, Huang ES, Mahesh A, Vonsattel JPG, Petersen AJ, Gomez-Pastor R, Ashe KH. (2019) A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients. Acta Neuropathol Commun. 7(1):111.
Smith BR, Nelson KM, Kemper LJ, Leinonen-Wright K, Petersen A, Keene CD, Ashe KH. (2019) A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease. Acta Neuropathol Commun. 7(1):124.
Liu P, Reichl JH, Rao ER, McNellis BM, Huang ES, Hemmy LS, Forster CL, Kuskowski MA, Borchelt DR, Vassar R, Ashe KH, Zahs KR. (2017) Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice. Journal of Alzheimer’s Disease. 56(2):743-761.
Zhao X, Kotilinek LA, Smith B, Hlynialuk C, Zahs K, Ramsden M, Cleary J, Ashe KH. (2016) Caspase-2 cleavage of tau reversibly impairs memory. Nature Medicine. 22(11):1268-1276.
Liu P, Reed MN, Kotilinek LA, Grant MKO, Forster CL, Qiang W, Shapiro SL, Reichl JH, Chiang ACA, Jankowsky JL, Wilmot CM, Cleary JP, Zahs KR, Ashe KH. (2015) Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration. Cell Reports. 11(11):1760-1771.
Liu P, Paulson JB, Forster CL, Shapiro SL, Ashe KH, Zahs KR. (2015) Characterization of a Novel Mouse Model of Alzheimer’s Disease–Amyloid Pathology and Unique β-Amyloid Oligomer Profile. PLoS One. 10(5).
Weitzner DS, Engler-Chiurazzi EB, Kotilinek LA, Ashe KH, Reed MN. (2015) Morris Water Maze Test: Optimization for Mouse Strain and Testing Environment. JoVE. 100: 52706.
Zahs KR, Ashe KH. More than a FAD: the in vivo effects of disease-linked presenilin-1 mutations. (2015) Neuron. 85(5):893-5.
Qi Y, Klyubin I, Harney SC, Hu N, Cullen WK, Grant MK, Steffen J, Wilson EN, Do Carmo S, Remy S, Fuhrmann M, Ashe KH, Cuello AC, Rowan MJ. (2014) Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents. Acta Neuropathol Commun. 2:175.
Ashe KH, Aguzzi A. (2013) Prions, prionoids and pathogenic proteins in Alzheimer disease. Prion. 7(1):55-9.
Handoko M, Grant M, Kuskowski M, Zahs KR, Wallin A, Blennow K, Ashe KH. (2013) Correlation of specific amyloid-β oligomers with tau in cerebrospinal fluid from cognitively normal older adults. JAMA Neurol. 70(5):594-9.
SE, Sherman MA, Grant M, Kuskowski M, Schneider JA, Bennett DA, Ashe KH. (2013) Brain amyloid-β oligomers in ageing and Alzheimer’s disease. Brain. 136(5):1383-98.
Zahs KR, Ashe KH. (2013) β-Amyloid oligomers in aging and Alzheimer’s disease. Front Aging Neurosci. 4;5:28.
De Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. (2012) Propagation of tau pathology in a model of early Alzheimer’s disease. Neuron. 73(4):685-97.
Orr ME, Pitstick R, Canine B, Ashe KH, Carlson GA. (2012) Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau. PLoS One. 7(6):e39328.
Liu P, Kemper LJ, Wang J, Zahs KR, Ashe KH, Pasinetti GM. (2011) Grape seed polyphenolic extract specifically decreases aβ*56 in the brains of Tg2576 mice. J Alzheimers Dis. 26(4):657-66.
McCarten JR, Anderson P, Kuskowski MA, McPherson SE, Borson S. (2011) Screening for cognitive impairment in an elderly veteran population: acceptability and results using different versions of the Mini-Cog. J Am Geriatr Soc. 59(2):309-13.
Reed MN, Hofmeister JJ, Jungbauer L, Welzel AT, Yu C, Sherman MA, Lesné S, LaDu MJ, Walsh DM, Ashe KH, Cleary JP. (2011) Cognitive effects of cell-derived and synthetically derived Aβ oligomers. Neurobiol Aging. 32(10):1784-94.
Ashe KH, Zahs KR. (2010) Probing the biology of Alzheimer’s disease in mice. Neuron. 66(5): 631-45.
Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK, Pitstick R, Carlson GA, Lanier LM, Yuan LL, Ashe KH, Liao D. (2010) Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron. 68:1067-1081.
Reed MN, Liu P, Kotilinek LA, Ashe KH. (2010) Effect size of reference memory deficits in the Morris water maze in Tg2576 mice. Behav Brain Res. 212(1):115-20.
Zahs KR, Ashe KH. (2010) ‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer’s disease? Trends Neurosci. 33:381-389.
Kotilinek LA, Westerman MA, Wang Q, Panizzon K, Lim GP, Simonyi A, Lesné S, Falinska A, Younkin LH, Younkin SG, Rowan M, Cleary J, Wallis RA, Sun GY, Cole G, Frautschy S, Anwyl R, Ashe KH. (2008) Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain, 131(Pt3):651-64.
Lesné S, Kotilinek L, Ashe KH. (2008) Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function. Neuroscience, 151:745-749.
Paulson JB, Ramsden M, Forster C, Sherman MA, McGowan E, Ashe KH. (2008) Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer’s disease. Am J Pathol. 173(3):762-72.
Poling A, Morgan-Paisley K, Panos JJ, Kim EM, O’Hare E, Cleary JP, Lesné S, Ashe KH, Porritt M, Baker LE. (2008) Oligomers of the amyloid-beta protein disrupt working memory: confirmation with two behavioral procedures. Behav Brain Res. 193(2):230-4.
Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT. (2008) In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci. 28(4):862-7.
Ashe KH. (2007) A tale about tau. N Engl J Med. 357(9):933-5.
Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puolivali J, Lesné S, Ashe KH, Muchowski PJ, Mucke L. (2007) Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J Biol Chem. 282:23818-23828.
Ma H, Lesné S, Kotilinek L, Steidl-Nichols JV, Sherman M, Younkin L, Younkin S, Forster C, Sergeant N, Delacourte A, Vassar R, Citron M, Kofuji P, Boland LM, Ashe KH. (2007) Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. Proc Natl Acad Sci U.S.A. 104(19):8167-72.
Ashe KH. (2006) Molecular basis of memory loss in the Tg2576 mouse model of Alzheimer’s disease. J Alzheimers Dis. 9(3 Suppl):123-6.
Ashe KH. (2006) In search of the molecular basis of memory loss in Alzheimer disease. Alzheimer Dis Assoc Disord. 20(4):200-1.
Spires TL, Orne JD, SantaCruz K, Pitstick R, Carlson GA, Ashe KH, Hyman BT. (2006) Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. Am J Pathol. 168:1598-1607.
Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH. (2006) A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 440:352-357.
Ashe KH. (2005) Mechanisms of memory loss in Abeta and tau mouse models. Biochem Soc Trans. 33(Pt 4):591-4.
Lesné S, Kotilinek L. (2005) Amyloid plaques and amyloid-beta oligomers: an ongoing debate. J Neurosci. 25(41):9319-20.
Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, SantaCruz K, Guimaraes A, Yue M, Lewis J, Carlson G, Hutton M, Ashe KH. (2005) Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci. 25:10637-10647.
SantaCruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, Kuskowski M, Hyman B, Hutton M, Ashe KH. (2005) Tau suppression in a neurodegenerative mouse model improves memory function. Science. 309:476-481.
Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, Hyman BT, Younkin S, Ashe KH. (2002) Reversible memory loss in a mouse transgenic model of Alzheimer’s disease. J Neurosci. 22(15):6331-5.
Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, Carlson GA, Younkin SG, Ashe KH. (2002) The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer’s disease. J Neurosci. 22(5):1858-67.
Ashe KH. (2001) Learning and memory in transgenic mice modeling Alzheimer’s disease. Learn Mem. 8(6):301-8.
Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG. (2001) Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer’s disease. J Neurosci. 21(2):372-81.
Ashe KH. (2000) Synaptic structure and function in transgenic APP mice. Ann N Y Acad Sci. 924:39-41.
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G. (1996) Correlative memory deficits, Aβ* elevation, and amyloid plaques in transgenic mice. Science. 274:99-102.