In 1906, the pathology of progressive dementia was first described by Dr. Alois Alzheimer and scientists began to study Alzheimer’s disease in laboratories and clinics around the world. Over a century later, we still lack a clear understanding of the fundamental biology and underlying cause of this devastating disease.

Grossman Center research examines the molecules and proteins involved in the development of Alzheimer’s disease. While many studies focus only on the hallmark amyloid plaques and tau tangles that accompany disease progression, we are targeting additional molecules that may be the more crucial disease mechanisms. As we hone in on the structure and function of these molecules, we aim to uncover and block the underlying cause of Alzheimer’s disease. We are driven to bring our research findings into the clinical realm to develop and test disease treatments. Our core team includes the Ashe lab  and Yuan lab, and we collaborate with several research groups at the University of Minnesota and other institutions. 

Building a network to strengthen brain connections

One of the greatest assets of the Grossman Center is the expansive network within the University and across the field with whom we work to advance Alzheimer’s disease research. Our center’s mission is driven by several innovative collaborations.  These partnerships bridge multiple disciplines, integrating their tools and techniques in novel ways to study Alzheimer’s disease and develop treatments.