Selected Yuan Publications

Smedley GD, Walker KE, Yuan SH. (2021) The Role of PERK in Understanding Development of Neurodegenerative Diseases. Int J Mol Sci. 22(15):8146.


Aulston B, Liu Q, Reilly P, Yuan SH. (2019) An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons. J Vis Exp. (147).


Winston CN, Aulston B, Rockenstein EM, Adame A, Prikhodko O, Dave KN, Mishra P, Rissman RA, Yuan SH. (2019) Neuronal Exosome-Derived Human Tau is Toxic to Recipient Mouse Neurons in vivo. J Alzheimers Dis. 67(2): 541-553.


Yuan SH, Wang SG. (2018) Alzheimer’s Dementia due to Suspected CTE from Subconcussive Head Impact. Case Rep Neurol Med. Ecollect2018.


Yuan SH, Hiramatsu N, Liu Q, Sun XV, Lenh D, Chan P, Chiang K, Koo EH, Kao AW, Litvan I, Lin JH. (2018) Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress. Human Molecular Genetics. 27(22): 3951–3963.


Reilly P, Winston CN, Baron KR, Trejo M, Rockenstein EM, Akers JC, Kfoury N, Diamond M, Masliah E, Rissman RA, Yuan SH. (2017) Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation. Neurobiol Dis. 106: 222-234.


Young JE, Boulanger-Weill J, Williams DA, Woodruff G, Buen F, Revilla AC, Herrera C, Israel MA, Yuan SH, Edland SD, Goldstein LS. (2015) Elucidating molecular phenotypes caused by the SORL1 Alzheimer’s disease genetic risk factor using human induced pluripotent stem cells. Cell Stem Cell. 16(4):373-85.


Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein LS, Wagner SL, Yuan SH. (2014) Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. JAMA Neurol. 71(12):1481-9.


Woodruff G, Young JE, Martinez FJ, Buen F, Gore A, Kinaga J, Li Z, Yuan SH, Zhang K, Goldstein LS. (2013) The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells. Cell Rep. 5(4):974-85.


Yuan SH, Shaner M. (2013) Bioengineered stem cells in neural development and neurodegeneration research. Ageing Res Rev. 12(3):739-48.


Ordonez MP, Roberts EA, Kidwell CU, Yuan SH, Plaisted WC, Goldstein LS. (2012) Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1. Hum Mol Genet. 21(12):2651-62.


Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. (2012) Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells. Nature. 482(7384):216-20.


DeQuach JA, Yuan SH, Goldstein LS, Christman KL. (2011) Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds. Tissue Eng Part A. 17(21-22):2583-92.


Yuan SH, Martin J, Elia J, Flippin J, Paramban RI, Hefferan MP, Vidal JG, Mu Y, Killian RL, Israel MA, Emre N, Marsala S, Marsala M, Gage FH, Goldstein LS, Carson CT. (2011) Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One. 6(3):e17540.


Dittmer S, Kovacs Z, Yuan SH, Siszler G, Kögl M, Summer H, Geerts A, Golz S, Shioda T, Methner A. (2011) TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex. J Cell Sci.124(2):252-60.


Yuan SH, Qiu Z, Ghosh A. (2011) TOX3 regulates calcium-dependent transcription in neurons. Proc Natl Acad Sci USA. 106(8):2909-14.