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Karen Hsiao Ashe, MD, PhD
 Karen
Hsiao Ashe, MD, PhD
Professor, Departments of Neurology and Neuroscience
Edmund Wallace and Anne Marie Tulloch Chairs in Neurology and Neuroscience
Director,
N. Bud Grossman Center for Memory Research and Care
hsiao005@umn.edu
Education
PhD, Neuroscience, Massachusetts Institute of Technology
MD, Harvard University
AB, Chemistry and Physics, Harvard University
Board Certification: American Academy of Neurology
Residency (Neurology), University of California, San Francisco
Transgenic animal models of Alzheimer’s and related disorders
I am delighted that the Tg2576 mouse model of pre-clinical Alzheimer’s
disease, developed in my laboratory, has been sent to more than 100 laboratories
around the world and has been used to generate over 500 publications. I
feel immensely gratified to see that at least 200 of these publications have
demonstrated the beneficial effects of various interventions, several of which
are now being tested in humans with Alzheimer’s disease. I am excited
about the prospect of developing safe means of preventing Alzheimer’s
disease. I believe that Tg2576 mice are trying to tell us how to achieve
this. If we pay close attention to what they are saying, we will be able
to prevent tens of millions of people from developing Alzheimer’s disease. Imagine
how wonderful that would be! I am fascinated by the rTg4510 mouse model
of fronto-temporal dementia, also developed in my laboratory, which shows many
features of the middle and late stages of Alzheimer’s disease. I
hope that our studies of Tg2576 and rTg4510 mice will enable us to understand
the connection between the early and late stages of Alzheimer’s disease. I
feel incredibly lucky to be working with extraordinary scientists to probe
the biology of all stages of Alzheimer’s disease using our mice.
Selected Publications
- K.H. Ashe
A
tale about tau.
New England Journal Medicine 357:933-5, 2007.
- H. Ma, S. Lesné, L. Kotilinek, J.V. Steidl-Nichols, M. Sherman,
L. Younkin, S. Younkin, C. Forster, N. Sergeant, A. Delacourte, R. Vassar,
M. Citron, P. Kofuji, L.M. Boland, K.H. Ashe
Involvement
of ß-site APP cleaving enzyme 1 (BACE1) in amyloid precursor
protein-mediated enhancement of memory and activity-dependent
synaptic plasticity.
PNAS 104:8167-72,
2007.
- Sylvain Lesné, Ming Teng Koh, Linda Kotilinek, Rakez Kayed, Charles
G. Glabe, Austin Yang, Michela Gallagher and Karen H. Ashe
A
specific amyloid-ß protein assembly in the brain impairs memory.
Nature 440:352-357, 2006.
- K. SantaCruz, J. Lewis, T. Spires, J. Paulson, L. Kotilinek, M. Ingelsson,
A. Guimaraes, M. DeTure, M. Ramsden, E. McGowan, C. Forster, M. Yue, J. Orne,
C. Janus, A. Mariash, M. Kuskowski, B. Hyman, M. Hutton, K.H. Ashe
Tau
suppression in a neurodegenerative mouse model improves memory function.
Science 309:476-81,
2005.
- J. Cleary, D. M. Walsh, J.J. Hofmeister, G.M. Shankar, M.A. Kuskowski,
D.J. Selkoe, K.H. Ashe
Natural
oligomers of the amyloid-ß protein specifically disrupt cognitive
function.
Nature
Neuroscience 8:79-84, 2005.
- Kotilinek, L.A., Bacskai, B., Westerman, M., Kawarabayashi, T., Younkin,
L., Hyman, B.T., Younkin, S., Ashe, K.H.
Reversible
memory loss in a mouse transgenic model of Alzheimer' disease.
Journal
of Neuroscience 22:6331-6335, 2002.
- Westerman, M., Cooper-Blacketer, D., Mariash, A., Kotilinek, L., Kawarabayashi,
T., Younkin, L.H., Carlson, G.A., Younkin, S.G., Ashe, K.H.
The
relationship between Aß and memory in the Tg2576 mouse model of
Alzheimer's disease.
Journal
of Neuroscience 22:1858-1867, 2002.
- Ashe, K. H
Learning
and memory in transgenic mice modeling Alzheimer's disease.
Learning and Memory 8:301-308,
2001
- P.F. Chapman, G.L. White, M.W. Jones, D. Cooper-Blacketer, V.J. Marshall,
M. Irizarry, L.H. Younkin, M.A. Good, T.V.P. Bliss, B.T. Hyman, S.G. Younkin,
K. Hsiao
Impaired synaptic plasticity and learning in aged amyloid precursor
protein transgenic mice.
Nature
Neuroscience 2:271-276, 1999.
- K. Hsiao, P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, S. Younkin, F.
Yang, G. Cole
Correlative memory deficits, Aß elevation, and amyloid
plaques in transgenic mice.
Science 274:99-102,
1996.
- K.K. Hsiao, D.R. Borchelt, K. Olson, R. Johannsdottir, R., C. Kitt, W.
Yunis, S. Xu, C. Eckman, S. Younkin, D. Price, C. Iadecola, H.B. Clark, G.
Carlson
Age-related
CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer
amyloid precursor proteins.
Neuron 15:1203-1218,
1995.
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