Tg2576 is made freely available to non-profit institutions worldwide, eventually becoming the most widely-used animal model of Alzheimer’s disease in the world.

Harvard University names Tg2576 one of the ten best medical discoveries of the year.

The Ashe Laboratory demonstrates that memory retention in demented rTg4510 mice is partially recoverable. This is the first time that recovery of memory function has been achieved after neuronal loss has occurred in a laboratory animal model of neurodegenerative disease.

Karen Ashe receives the MetLife Award for Alzheimer’s Disease Research [more]

The Ashe Laboratory discovers Aß* (A Beta Star), a distinct form of the Aß protein and demonstrates that it is present in and induces memory and cognitive deficits in laboratory animals.

The Memory Clinic opens its doors.

Karen Ashe receives the Potamkin Prize for Research in Pick’s, Alzheimer’s, and Related Diseases. [more]

The Center for Memory Research and Care is established.

In a poll published in Nature Medicine, Alzheimer’s researchers worldwide name the discovery of Aß* as the most important discovery in the field in the last three years (tied for first).  The recovery of memory function in rTg4510 mice is named the third most important discovery.  Three discoveries  from our laboratory make the top list.